The gentle wall-flow method dissolves the powder without agitation
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HLC cultures were incubated with conventional probe substrates for CYP3A4 (6 M midazolam), CYP2C9 (10 M diclofenac), and CYP2D6 (10 M dextromethorphan) for 2 hours
What to Expect in Months 7-11 Essentially no side effects: Appetite suppression continues (desired effect), but GI symptoms gone Weight loss velocity slows: From 0.8kg/week (months 3-6) to 0.3-0.5kg/week Plateau around week 40-48: Weight stabilizes, no longer losing despite continued medication Total weight loss: Average 20-24% from baseline (matching or exceeding surgical outcomes) Focus shifts to maintenance: Accepting current weight, preventing regain Plateau frustration: Not a side effect but an emotional challenge 2 Final Strategies for Months 7-11 20
Complementary Approaches: The selectivity of AOD-9604 allows flexible combination with other interventions
It is not appropriate for everyone, and understanding who benefits most helps researchers make informed decisions about whether the added complexity and cost are justified
